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185
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ECCC
2008
15 years 6 months ago
2008
Any proof of P = NP will have to overcome two barriers: relativization and natural proofs. Yet over the last decade, we have seen circuit lower bounds (for example, that PP does n...
154
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BMCBI
2006
2006
On single and multiple models of protein families for the detection of remote sequence relationships
15 years 6 months ago
Background: The detection of relationships between a protein sequence of unknown function and a sequence whose function has been characterised enables the transfer of functional a...
170
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BMCBI
2006
15 years 6 months ago
2006
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
196
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BMCBI
2006
15 years 6 months ago
2006
Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because ...
187
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BMCBI
2006
15 years 6 months ago
2006
Background: The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of t...