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BMCBI
2008
138views more  BMCBI 2008»
15 years 7 months ago
Automated simultaneous analysis phylogenetics (ASAP): an enabling tool for phlyogenomics
Background: The availability of sequences from whole genomes to reconstruct the tree of life has the potential to enable the development of phylogenomic hypotheses in ways that ha...
Indra Neil Sarkar, Mary G. Egan, Gloria M. Coruzzi...
BMCBI
2008
103views more  BMCBI 2008»
15 years 7 months ago
Detection of protein catalytic residues at high precision using local network properties
Background: Identifying the active site of an enzyme is a crucial step in functional studies. While protein sequences and structures can be experimentally characterized, determini...
Patrick Slama, Ioannis Filippis, Michael Lappe
BMCBI
2008
130views more  BMCBI 2008»
15 years 7 months ago
Structural descriptor database: a new tool for sequence-based functional site prediction
Background: The Structural Descriptor Database (SDDB) is a web-based tool that predicts the function of proteins and functional site positions based on the structural properties o...
Juliana S. Bernardes, Jorge H. Fernandez, Ana Tere...
BMCBI
2008
148views more  BMCBI 2008»
15 years 7 months ago
Discovering biclusters in gene expression data based on high-dimensional linear geometries
Background: In DNA microarray experiments, discovering groups of genes that share similar transcriptional characteristics is instrumental in functional annotation, tissue classifi...
Xiangchao Gan, Alan Wee-Chung Liew, Hong Yan
BMCBI
2008
119views more  BMCBI 2008»
15 years 7 months ago
A new method for 2D gel spot alignment: application to the analysis of large sample sets in clinical proteomics
Background: In current comparative proteomics studies, the large number of images generated by 2D gels is currently compared using spot matching algorithms. Unfortunately, differe...
Sabine Pérès, Laurence Molina, Nicol...
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