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BMCBI
2007
129views more  BMCBI 2007»
15 years 6 months ago
HoughFeature, a novel method for assessing drug effects in three-color cDNA microarray experiments
Background: Three-color microarray experiments can be performed to assess drug effects on the genomic scale. The methodology may be useful in shortening the cycle, reducing the co...
Hongya Zhao, Hong Yan
BMCBI
2008
178views more  BMCBI 2008»
15 years 6 months ago
A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic ana
Background: Protein remote homology detection and fold recognition are central problems in bioinformatics. Currently, discriminative methods based on support vector machine (SVM) ...
Bin Liu, Xiaolong Wang, Lei Lin, Qiwen Dong, Xuan ...
BMCBI
2008
139views more  BMCBI 2008»
15 years 6 months ago
Abbreviation definition identification based on automatic precision estimates
Background: The rapid growth of biomedical literature presents challenges for automatic text processing, and one of the challenges is abbreviation identification. The presence of ...
Sunghwan Sohn, Donald C. Comeau, Won Kim, W. John ...
BMCBI
2006
144views more  BMCBI 2006»
15 years 6 months ago
Development and implementation of an algorithm for detection of protein complexes in large interaction networks
Background: After complete sequencing of a number of genomes the focus has now turned to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass spectrometry e...
Md. Altaf-Ul-Amin, Yoko Shinbo, Kenji Mihara, Ken ...
BMCBI
2007
126views more  BMCBI 2007»
15 years 6 months ago
Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation
Background: Biochemical investigations over the last decades have elucidated an increasingly complete image of the cellular metabolism. To derive a systems view for the regulation...
Gunnar Schramm, Marc Zapatka, Roland Eils, Rainer ...