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BMCBI
2005
122views more  BMCBI 2005»
15 years 6 months ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
BMCBI
2005
201views more  BMCBI 2005»
15 years 6 months ago
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...
Yunlong Liu, Matthew P. Vincenti, Hiroki Yokota
BMCBI
2005
163views more  BMCBI 2005»
15 years 6 months ago
CoaSim: A flexible environment for simulating genetic data under coalescent models
Background: Coalescent simulations are playing a large role in interpreting large scale intraspecific sequence or polymorphism surveys and for planning and evaluating association ...
Thomas Mailund, Mikkel H. Schierup, Christian N. S...
BMCBI
2005
87views more  BMCBI 2005»
15 years 6 months ago
Efficient decoding algorithms for generalized hidden Markov model gene finders
Background: The Generalized Hidden Markov Model (GHMM) has proven a useful framework for the task of computational gene prediction in eukaryotic genomes, due to its flexibility an...
William H. Majoros, Mihaela Pertea, Arthur L. Delc...
BMCBI
2005
115views more  BMCBI 2005»
15 years 6 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
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