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» On the Purpose of Object-Oriented Analysis
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BMCBI
2010
92views more  BMCBI 2010»
15 years 6 months ago
HORI: a web server to compute Higher Order Residue Interactions in protein structures
Background: Folding of a protein into its three dimensional structure is influenced by both local and global interactions within a protein. Higher order residue interactions, like...
Pandurangan Sundaramurthy, Khader Shameer, Raashi ...
BMCBI
2010
114views more  BMCBI 2010»
15 years 6 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
BMCBI
2010
155views more  BMCBI 2010»
15 years 6 months ago
A flexible R package for nonnegative matrix factorization
Background: Nonnegative Matrix Factorization (NMF) is an unsupervised learning technique that has been applied successfully in several fields, including signal processing, face re...
Renaud Gaujoux, Cathal Seoighe
BMCBI
2007
86views more  BMCBI 2007»
15 years 6 months ago
Detecting microsatellites within genomes: significant variation among algorithms
Background: Microsatellites are short, tandemly-repeated DNA sequences which are widely distributed among genomes. Their structure, role and evolution can be analyzed based on exh...
Sébastien Leclercq, Eric Rivals, Philippe J...
BMCBI
2007
135views more  BMCBI 2007»
15 years 6 months ago
Measuring similarities between gene expression profiles through new data transformations
Background: Clustering methods are widely used on gene expression data to categorize genes with similar expression profiles. Finding an appropriate (dis)similarity measure is crit...
Kyungpil Kim, Shibo Zhang, Keni Jiang, Li Cai, In-...