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» On the Purpose of Object-Oriented Analysis
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BMCBI
2008
130views more  BMCBI 2008»
15 years 6 months ago
IDEA: Interactive Display for Evolutionary Analyses
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
Amy Egan, Anup Mahurkar, Jonathan Crabtree, Jonath...
BMCBI
2007
109views more  BMCBI 2007»
15 years 6 months ago
Computational RNA secondary structure design: empirical complexity and improved methods
Background: We investigate the empirical complexity of the RNA secondary structure design problem, that is, the scaling of the typical difficulty of the design task for various cl...
Rosalía Aguirre-Hernández, Holger H....
BMCBI
2008
108views more  BMCBI 2008»
15 years 6 months ago
New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroun
Background: Few genetic factors predisposing to the sporadic form of amyotrophic lateral sclerosis (ALS) have been identified, but the pathology itself seems to be a true multifac...
Silvana Penco, Massimo Buscema, Maria Cristina Pat...
BMCBI
2008
132views more  BMCBI 2008»
15 years 6 months ago
The SeqWord Genome Browser: an online tool for the identification and visualization of atypical regions of bacterial genomes thr
Background: Data mining in large DNA sequences is a major challenge in microbial genomics and bioinformatics. Oligonucleotide usage (OU) patterns provide a wealth of information f...
Hamilton Ganesan, Anna S. Rakitianskaia, Colin F. ...
BMCBI
2005
140views more  BMCBI 2005»
15 years 6 months ago
Dissecting systems-wide data using mixture models: application to identify affected cellular processes
Background: Functional analysis of data from genome-scale experiments, such as microarrays, requires an extensive selection of differentially expressed genes. Under many condition...
J. Peter Svensson, Renée X. de Menezes, Ing...