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» On the Network Complexity of Selection
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BMCBI
2007
107views more  BMCBI 2007»
15 years 6 months ago
A computational approach for detecting peptidases and their specific inhibitors at the genome level
Background: Peptidases are proteolytic enzymes responsible for fundamental cellular activities in all organisms. Apparently about 2–5% of the genes encode for peptidases, irresp...
Lisa Bartoli, Remo Calabrese, Piero Fariselli, Dam...
JACM
2008
91views more  JACM 2008»
15 years 6 months ago
On the minimization of XPath queries
XML queries are usually expressed by means of XPath expressions identifying portions of the selected documents. An XPath expression defines a way of navigating an XML tree and ret...
Sergio Flesca, Filippo Furfaro, Elio Masciari
JACM
2006
99views more  JACM 2006»
15 years 6 months ago
Finding a maximum likelihood tree is hard
Abstract. Maximum likelihood (ML) is an increasingly popular optimality criterion for selecting evolutionary trees [Felsenstein 1981]. Finding optimal ML trees appears to be a very...
Benny Chor, Tamir Tuller
JCB
2006
107views more  JCB 2006»
15 years 6 months ago
Maximum Likelihood Molecular Clock Comb: Analytic Solutions
Maximum likelihood (ML) is increasingly used as an optimality criterion for selecting evolutionary trees, but finding the global optimum is a hard computational task. Because no g...
Benny Chor, Amit Khetan, Sagi Snir
JIB
2006
106views more  JIB 2006»
15 years 6 months ago
A structural keystone for drug design
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
Kristian Rother, Mathias Dunkel, Elke Michalsky, S...
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