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BMCBI
2007
147views more  BMCBI 2007»
15 years 6 months ago
Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model
Background: Serial analysis of gene expression (SAGE) is used to obtain quantitative snapshots of the transcriptome. These profiles are count-based and are assumed to follow a Bin...
Scott D. Zuyderduyn
BMCBI
2007
134views more  BMCBI 2007»
15 years 6 months ago
Nearest Neighbor Networks: clustering expression data based on gene neighborhoods
Background: The availability of microarrays measuring thousands of genes simultaneously across hundreds of biological conditions represents an opportunity to understand both indiv...
Curtis Huttenhower, Avi I. Flamholz, Jessica N. La...
BMCBI
2008
105views more  BMCBI 2008»
15 years 6 months ago
SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes
Background: High throughput microarray technologies have afforded the investigation of genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software packa...
Raj Chari, Bradley P. Coe, Craig Wedseltoft, Marie...
BMCBI
2008
117views more  BMCBI 2008»
15 years 6 months ago
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass sp
Background: Metabolomics, petroleum and biodiesel chemistry, biomarker discovery, and other fields which rely on high-resolution profiling of complex chemical mixtures generate da...
Minho Chae, Robert J. Shmookler Reis, John J. Thad...
CE
2008
128views more  CE 2008»
15 years 6 months ago
Beyond threaded discussion: Representational guidance in asynchronous collaborative learning environments
Although most online learning environments are predominately text based, researchers have argued that representational support for the conceptual structure of a problem would addr...
Daniel D. Suthers, Ravi K. Vatrapu, Richard Medina...