Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
Teaser Figure: Left: Brain, visualized using silhouettes, the lesion's spatial depth is displayed using a ring. Center: Combined rendering of brain tissue, skull and fiber tr...
Christian Rieder, Felix Ritter, Matthias Raspe, He...
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Computational protein design can be formulated as an optimization problem, where the objective is to identify the sequence of amino acids that minimizes the energy of a given prot...
Noah Ollikainen, Ellen Sentovich, Carlos Coelho, A...
Submodular function maximization is a central problem in combinatorial optimization, generalizing many important problems including Max Cut in directed/undirected graphs and in hy...
Jon Lee, Vahab S. Mirrokni, Viswanath Nagarajan, M...