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BMCBI
2010
185views more  BMCBI 2010»
15 years 6 months ago
ABCtoolbox: a versatile toolkit for approximate Bayesian computations
Background: The estimation of demographic parameters from genetic data often requires the computation of likelihoods. However, the likelihood function is computationally intractab...
Daniel Wegmann, Christoph Leuenberger, Samuel Neue...
BMCBI
2007
108views more  BMCBI 2007»
15 years 6 months ago
Publishing perishing? Towards tomorrow's information architecture
Scientific articles are tailored to present information in human-readable aliquots. Although the Internet has revolutionized the way our society thinks about information, the trad...
Michael R. Seringhaus, Mark B. Gerstein
BMCBI
2008
105views more  BMCBI 2008»
15 years 6 months ago
Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
Ie-Bin Lian, Yi-Hsien Lin, Ying-Chao Lin, Hsin-Cho...
BMCBI
2007
105views more  BMCBI 2007»
15 years 6 months ago
Generating confidence intervals on biological networks
Background: In the analysis of networks we frequently require the statistical significance of some network statistic, such as measures of similarity for the properties of interact...
Thomas Thorne, Michael P. H. Stumpf
BMCBI
2010
132views more  BMCBI 2010»
15 years 6 months ago
Parallel multiplicity and error discovery rate (EDR) in microarray experiments
Background: In microarray gene expression profiling experiments, differentially expressed genes (DEGs) are detected from among tens of thousands of genes on an array using statist...
Wayne Wenzhong Xu, Clay J. Carter