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168
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BMCBI
2010
136views more  BMCBI 2010»
15 years 7 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
217
Voted
BMCBI
2006
159views more  BMCBI 2006»
15 years 7 months ago
MultiSeq: unifying sequence and structure data for evolutionary analysis
Background: Since the publication of the first draft of the human genome in 2000, bioinformatic data have been accumulating at an overwhelming pace. Currently, more than 3 million...
Elijah Roberts, John Eargle, Dan Wright, Zaida Lut...
209
Voted
BMCBI
2005
151views more  BMCBI 2005»
15 years 6 months ago
stam - a Bioconductor compliant R package for structured analysis of microarray data
Background: Genome wide microarray studies have the potential to unveil novel disease entities. Clinically homogeneous groups of patients can have diverse gene expression profiles...
Claudio Lottaz, Rainer Spang
211
Voted
BMCBI
2010
153views more  BMCBI 2010»
15 years 6 months ago
Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massi
Background: Massively parallel sequencing readouts of epigenomic assays are enabling integrative genome-wide analyses of genomic and epigenomic variation. Pash 3.0 performs sequen...
Cristian Coarfa, Fuli Yu, Christopher A. Miller, Z...
ESEM
2010
ACM
15 years 5 months ago
Strengthening the empirical analysis of the relationship between Linus' Law and software security
Open source software is often considered to be secure because large developer communities can be leveraged to find and fix security vulnerabilities. Eric Raymond states Linus’ L...
Andrew Meneely, Laurie A. Williams