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BMCBI
2007
142views more  BMCBI 2007»
15 years 7 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2008
124views more  BMCBI 2008»
15 years 7 months ago
A probe-treatment-reference (PTR) model for the analysis of oligonucleotide expression microarrays
Background: Microarray pre-processing usually consists of normalization and summarization. Normalization aims to remove non-biological variations across different arrays. The norm...
Huanying Ge, Chao Cheng, Lei M. Li
BMCBI
2008
172views more  BMCBI 2008»
15 years 7 months ago
Compo: composite motif discovery using discrete models
Background: Computational discovery of motifs in biomolecular sequences is an established field, with applications both in the discovery of functional sites in proteins and regula...
Geir Kjetil Sandve, Osman Abul, Finn Drablø...
BMCBI
2006
129views more  BMCBI 2006»
15 years 7 months ago
BIPAD: A web server for modeling bipartite sequence elements
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...
Chengpeng Bi, Peter K. Rogan
BMCBI
2007
94views more  BMCBI 2007»
15 years 7 months ago
Model based analysis of real-time PCR data from DNA binding dye protocols
Background: Reverse transcription followed by real-time PCR is widely used for quantification of specific mRNA, and with the use of double-stranded DNA binding dyes it is becoming...
Mariano J. Alvarez, Guillermo J. Vila-Ortiz, Maria...