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BIOINFORMATICS
2008
172views more  BIOINFORMATICS 2008»
15 years 6 months ago
Fitting a geometric graph to a protein-protein interaction network
Motivation: Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between...
Desmond J. Higham, Marija Rasajski, Natasa Przulj
BMCBI
2010
148views more  BMCBI 2010»
15 years 6 months ago
Calling SNPs without a reference sequence
Background: The most common application for the next-generation sequencing technologies is resequencing, where short reads from the genome of an individual are aligned to a refere...
Aakrosh Ratan, Yu Zhang, Vanessa M. Hayes, Stephan...
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
15 years 6 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
BIOINFORMATICS
2008
106views more  BIOINFORMATICS 2008»
15 years 6 months ago
Small RNA gene identification and mRNA target predictions in bacteria
Motivation: Bacterial small ribonucleic acids (sRNAs) that are not ribosomal and transfer or messenger RNAs were initially identified in the sixties whereas their molecular functi...
Christophe Pichon, Brice Felden
BMCBI
2010
102views more  BMCBI 2010»
15 years 6 months ago
Identification of recurrent regions of copy-number variants across multiple individuals
Background: Algorithms and software for CNV detection have been developed, but they detect the CNV regions sample-by-sample with individual-specific breakpoints, while common CNV ...
Teo Shu Mei, Agus Salim, Stefano Calza, Ku Chee Se...
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