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BMCBI
2010
161views more  BMCBI 2010»
15 years 6 months ago
CGHpower: exploring sample size calculations for chromosomal copy number experiments
Background: Determining a suitable sample size is an important step in the planning of microarray experiments. Increasing the number of arrays gives more statistical power, but ad...
Ilari Scheinin, Jose A. Ferreira, Sakari Knuutila,...
BMCBI
2010
102views more  BMCBI 2010»
15 years 6 months ago
Identification of recurrent regions of copy-number variants across multiple individuals
Background: Algorithms and software for CNV detection have been developed, but they detect the CNV regions sample-by-sample with individual-specific breakpoints, while common CNV ...
Teo Shu Mei, Agus Salim, Stefano Calza, Ku Chee Se...
BMCBI
2010
118views more  BMCBI 2010»
15 years 6 months ago
Bacillus anthracis genome organization in light of whole transcriptome sequencing
Emerging knowledge of whole prokaryotic transcriptomes could validate a number of theoretical concepts introduced in the early days of genomics. What are the rules connecting gene...
Jeffrey Martin, Wenhan Zhu, Karla D. Passalacqua, ...
BMCBI
2007
99views more  BMCBI 2007»
15 years 6 months ago
Flexible mapping of homology onto structure with Homolmapper
Background: Over the past decade, a number of tools have emerged for the examination of homology relationships among protein sequences in a structural context. Most recent softwar...
Nathan C. Rockwell, J. Clark Lagarias
BMCBI
2007
129views more  BMCBI 2007»
15 years 6 months ago
A novel approach to sequence validating protein expression clones with automated decision making
Background: Whereas the molecular assembly of protein expression clones is readily automated and routinely accomplished in high throughput, sequence verification of these clones i...
Elena Taycher, Andreas Rolfs, Yanhui Hu, Dongmei Z...