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BMCBI
2007
122views more  BMCBI 2007»
15 years 7 months ago
TAP score: torsion angle propensity normalization applied to local protein structure evaluation
Background: Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to disti...
Silvio C. E. Tosatto, Roberto Battistutta
BMCBI
2008
149views more  BMCBI 2008»
15 years 7 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal
BMCBI
2006
137views more  BMCBI 2006»
15 years 6 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...
BMCBI
2006
169views more  BMCBI 2006»
15 years 6 months ago
Machine learning techniques in disease forecasting: a case study on rice blast prediction
Background: Diverse modeling approaches viz. neural networks and multiple regression have been followed to date for disease prediction in plant populations. However, due to their ...
Rakesh Kaundal, Amar S. Kapoor, Gajendra P. S. Rag...
BMCBI
2007
102views more  BMCBI 2007»
15 years 6 months ago
qPIPSA: Relating enzymatic kinetic parameters and interaction fields
Background: The simulation of metabolic networks in quantitative systems biology requires the assignment of enzymatic kinetic parameters. Experimentally determined values are ofte...
Razif R. Gabdoulline, Matthias Stein, Rebecca C. W...
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