24105 search results - page 4266 / 4821 » Models in Information Retrieval |
226
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BMCBI
2010
15 years 7 months ago
2010
Background: Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures in underlying genomic segments that can be r...
196
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BMCBI
2010
15 years 7 months ago
2010
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
221
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BMCBI
2008
15 years 7 months ago
2008
Background: Protein secondary structure prediction method based on probabilistic models such as hidden Markov model (HMM) appeals to many because it provides meaningful informatio...
202
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BMCBI
2007
15 years 7 months ago
2007
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
232
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BMCBI
2008
15 years 7 months ago
2008
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...