Nonlinear random effects models with finite mixture structures are used to identify polymorphism in pharmacokinetic/ pharmacodynamic (PK/PD) phenotypes. An EM algorithm for maxim...
Xiaoning Wang, Alan Schumitzky, David Z. D'Argenio
This paper extends the application of the Cantor metric as a mathematical tool for defining causalities from pure discrete models to mixed-signal and hybrid models. Using the Cant...
Abstract. Event-B is a formal method for modeling and verifying consistency of systems. In formal methods such as Event-B, refinement is the process of enriching or modifying an a...
In practice, a pure top-down and refinement-based development process is not applicable. A more iterative and incremental approach is usually applied with respect to changing req...
Rapid development of information technology such as mobile terminals and GPS systems enabled information services that provide location-oriented information based on users’ posit...