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BMCBI
2010
150views more  BMCBI 2010»
15 years 6 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2010
125views more  BMCBI 2010»
15 years 6 months ago
Haplotype allelic classes for detecting ongoing positive selection
Background: Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures in underlying genomic segments that can be r...
Julie Hussin, Philippe Nadeau, Jean-Françoi...
BMCBI
2010
95views more  BMCBI 2010»
15 years 6 months ago
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
Background: In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two de...
Emidio Capriotti, Marc A. Martí-Renom
BMCBI
2010
118views more  BMCBI 2010»
15 years 6 months ago
Towards realistic benchmarks for multiple alignments of non-coding sequences
Background: With the continued development of new computational tools for multiple sequence alignment, it is necessary today to develop benchmarks that aid the selection of the mo...
Jaebum Kim, Saurabh Sinha
BMCBI
2010
96views more  BMCBI 2010»
15 years 6 months ago
Incorporating gene co-expression network in identification of cancer prognosis markers
Background: Extensive biomedical studies have shown that clinical and environmental risk factors may not have sufficient predictive power for cancer prognosis. The development of ...
Shuangge Ma, Mingyu Shi, Yang Li, Danhui Yi, Ben-C...
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