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BMCBI
2010
139views more  BMCBI 2010»
15 years 7 months ago
A global optimization algorithm for protein surface alignment
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
Paola Bertolazzi, Concettina Guerra, Giampaolo Liu...
BMCBI
2007
117views more  BMCBI 2007»
15 years 7 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2008
135views more  BMCBI 2008»
15 years 7 months ago
Functional site prediction selects correct protein models
Background: The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possibl...
Vijayalakshmi Chelliah, William R. Taylor
BMCBI
2006
116views more  BMCBI 2006»
15 years 7 months ago
Gene annotation and network inference by phylogenetic profiling
Background: Phylogenetic analysis is emerging as one of the most informative computational methods for the annotation of genes and identification of evolutionary modules of functi...
Jie Wu, Zhenjun Hu, Charles DeLisi
BMCBI
2006
127views more  BMCBI 2006»
15 years 7 months ago
A graph-search framework for associating gene identifiers with documents
Background: One step in the model organism database curation process is to find, for each article, the identifier of every gene discussed in the article. We consider a relaxation ...
William W. Cohen, Einat Minkov
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