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BMCBI
2010
126views more  BMCBI 2010»
15 years 4 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
AOSD
2011
ACM
15 years 1 months ago
Closure joinpoints: block joinpoints without surprises
Block joinpoints allow programmers to explicitly mark regions of base code as “to be advised”, thus avoiding the need to extract the block into a method just for the sake of c...
Eric Bodden
BMCBI
2010
137views more  BMCBI 2010»
15 years 1 months ago
The ancient history of the structure of ribonuclease P and the early origins of Archaea
Background: Ribonuclease P is an ancient endonuclease that cleaves precursor tRNA and generally consists of a catalytic RNA subunit (RPR) and one or more proteins (RPPs). It repre...
Feng-Jie Sun, Gustavo Caetano-Anollés
BMCBI
2010
102views more  BMCBI 2010»
15 years 1 months ago
Predicting protein-protein interactions in unbalanced data using the primary structure of proteins
Background: Elucidating protein-protein interactions (PPIs) is essential to constructing protein interaction networks and facilitating our understanding of the general principles ...
Chi-Yuan Yu, Lih-Ching Chou, Darby Tien-Hao Chang
BMCBI
2011
15 years 1 months ago
Simulated evolution applied to study the genetic code optimality using a model of codon reassignments
Background: As the canonical code is not universal, different theories about its origin and organization have appeared. The optimization or level of adaptation of the canonical ge...
Jose Santos, Ángel Monteagudo