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BMCBI
2006
108views more  BMCBI 2006»
15 years 6 months ago
A new pooling strategy for high-throughput screening: the Shifted Transversal Design
Background: In binary high-throughput screening projects where the goal is the identification of low-frequency events, beyond the obvious issue of efficiency, false positives and ...
Nicolas Thierry-Mieg
BMCBI
2006
105views more  BMCBI 2006»
15 years 6 months ago
CRNPRED: highly accurate prediction of one-dimensional protein structures by large-scale critical random networks
Background: One-dimensional protein structures such as secondary structures or contact numbers are useful for three-dimensional structure prediction and helpful for intuitive unde...
Akira R. Kinjo, Ken Nishikawa
BMCBI
2005
108views more  BMCBI 2005»
15 years 6 months ago
SplitTester: software to identify domains responsible for functional divergence in protein family
Background: Many protein families have undergone functional divergence after gene duplications such that current subgroups of the family carry out overlapping but distinct biologi...
Xiang Gao, Kent Vander Velden, Daniel F. Voytas, X...
BMCBI
2004
96views more  BMCBI 2004»
15 years 6 months ago
A hybrid clustering approach to recognition of protein families in 114 microbial genomes
Background: Grouping proteins into sequence-based clusters is a fundamental step in many bioinformatic analyses (e.g., homology-based prediction of structure or function). Standar...
Timothy J. Harlow, J. Peter Gogarten, Mark A. Raga...
NAR
2002
89views more  NAR 2002»
15 years 6 months ago
Transcription Regulatory Regions Database (TRRD): its status in 2002
Transcription Regulatory Regions Database (TRRD) is an informational resource containing an integrated description of the gene transcription regulation. An entry of the database c...
Nikolay A. Kolchanov, Elena V. Ignatieva, Elena A....