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171
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BMCBI
2010
15 years 7 months ago
2010
Background: Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing met...
203
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BMCBI
2010
15 years 7 months ago
2010
Background: The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge da...
183
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BMCBI
2010
2010
On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence
15 years 7 months ago
Background: In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput gen...
184
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BMCBI
2010
15 years 7 months ago
2010
Background: Sustained research on the problem of determining which genes are differentially expressed on the basis of microarray data has yielded a plethora of statistical algorit...
172
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BMCBI
2010
15 years 7 months ago
2010
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...