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BMCBI
2010
132views more  BMCBI 2010»
15 years 7 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
BMCBI
2008
179views more  BMCBI 2008»
15 years 7 months ago
Bayesian modeling of recombination events in bacterial populations
Background: We consider the discovery of recombinant segments jointly with their origins within multilocus DNA sequences from bacteria representing heterogeneous populations of fa...
Pekka Marttinen, Adam Baldwin, William P. Hanage, ...
BMCBI
2008
84views more  BMCBI 2008»
15 years 7 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2008
179views more  BMCBI 2008»
15 years 7 months ago
Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists
Background: In DNA microarray gene expression profiling studies, a fundamental task is to extract statistically significant genes that meet certain research hypothesis. Currently,...
Xutao Deng, Jun Xu, Charles Wang
IEAAIE
2009
Springer
16 years 1 months ago
Incremental Mining of Ontological Association Rules in Evolving Environments
The process of knowledge discovery from databases is a knowledge intensive, highly user-oriented practice, thus has recently heralded the development of ontology-incorporated data ...
Ming-Cheng Tseng, Wen-Yang Lin