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BMCBI
2008
84views more  BMCBI 2008»
15 years 6 months ago
poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening
Background: A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS) in drug di...
Raghunandan M. Kainkaryam, Peter J. Woolf
BMCBI
2007
159views more  BMCBI 2007»
15 years 6 months ago
Detecting differential expression in microarray data: comparison of optimal procedures
Background: Many procedures for finding differentially expressed genes in microarray data are based on classical or modified t-statistics. Due to multiple testing considerations, ...
Elena Perelman, Alexander Ploner, Stefano Calza, Y...
CN
2007
133views more  CN 2007»
15 years 6 months ago
Automatic high-performance reconstruction and recovery
Self-protecting systems require the ability to instantaneously detect malicious activity at run-time and prevent execution. We argue that it is impossible to perfectly self-protec...
Ashvin Goel, Wu-chang Feng, Wu-chi Feng, David Mai...
IPM
2007
139views more  IPM 2007»
15 years 6 months ago
"What is a good digital library?" - A quality model for digital libraries
In this article, we elaborate on the meaning of quality in digital libraries (DLs) by proposing a model that is deeply grounded in a formal framework for digital libraries: 5S (St...
Marcos André Gonçalves, Bárba...
VLC
2008
191views more  VLC 2008»
15 years 6 months ago
Visual specification of measurements and redesigns for domain specific visual languages
Ensuring model quality is a key success factor in many computer science areas, and becomes crucial in recent software engineering paradigms like the one proposed by model-driven s...
Esther Guerra, Juan de Lara, Paloma Díaz