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UAI
2000
15 years 8 months ago
Variational Relevance Vector Machines
The Support Vector Machine (SVM) of Vapnik [9] has become widely established as one of the leading approaches to pattern recognition and machine learning. It expresses predictions...
Christopher M. Bishop, Michael E. Tipping
BMCBI
2010
141views more  BMCBI 2010»
15 years 7 months ago
BioPhysConnectoR: Connecting Sequence Information and Biophysical Models
Background: One of the most challenging aspects of biomolecular systems is the understanding of the coevolution in and among the molecule(s). A complete, theoretical picture of th...
Franziska Hoffgaard, Philipp Weil, Kay Hamacher
BMCBI
2008
152views more  BMCBI 2008»
15 years 7 months ago
Predicting biological system objectives de novo from internal state measurements
Background: Optimization theory has been applied to complex biological systems to interrogate network properties and develop and refine metabolic engineering strategies. For examp...
Erwin P. Gianchandani, Matthew A. Oberhardt, Antho...
BMCBI
2007
107views more  BMCBI 2007»
15 years 7 months ago
Reuse of structural domain-domain interactions in protein networks
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...
Benjamin Schuster-Böckler, Alex Bateman
BMCBI
2008
128views more  BMCBI 2008»
15 years 7 months ago
Validation of an NSP-based (negative selection pattern) gene family identification strategy
Background: Gene family identification from ESTs can be a valuable resource for analysis of genome evolution but presents unique challenges in organisms for which the entire genom...
Ronald L. Frank, Cyriac Kandoth, Fikret Erç...