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175
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BMCBI
2004
15 years 6 months ago
2004
Background: Regulatory regions that function in DNA replication and gene transcription contain specific sequences that bind proteins as well as less-specific sequences in which th...
181
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BMCBI
2004
15 years 6 months ago
2004
Background: Recently, mass spectrometry data have been mined using a genetic algorithm to produce discriminatory models that distinguish healthy individuals from those with cancer...
167
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BMCBI
2004
15 years 6 months ago
2004
Background: Microarray data must be normalized because they suffer from multiple biases. We have identified a source of spatial experimental variability that significantly affects...
181
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BMCBI
2004
15 years 6 months ago
2004
Background: The rapidly increasing number of completely sequenced genomes led to the establishment of the COG-database which, based on sequence homologies, assigns similar protein...
200
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BMCBI
2004
15 years 6 months ago
2004
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...