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BMCBI
2007
135views more  BMCBI 2007»
15 years 6 months ago
Automatic extraction of reliable regions from multiple sequence alignments
Background: High quality multiple alignments are crucial in the transfer of annotation from one genome to another. Multiple alignment methods strive to achieve ever increasing lev...
Timo Lassmann, Erik L. L. Sonnhammer
BMCBI
2007
153views more  BMCBI 2007»
15 years 6 months ago
Analysis of nanopore detector measurements using Machine-Learning methods, with application to single-molecule kinetic analysis
Background: A nanopore detector has a nanometer-scale trans-membrane channel across which a potential difference is established, resulting in an ionic current through the channel ...
Matthew Landry, Stephen Winters-Hilt
BMCBI
2007
105views more  BMCBI 2007»
15 years 6 months ago
Finding regulatory elements and regulatory motifs: a general probabilistic framework
Over the last two decades a large number of algorithms has been developed for regulatory motif finding. Here we show how many of these algorithms, especially those that model bind...
Erik van Nimwegen
BMCBI
2007
131views more  BMCBI 2007»
15 years 6 months ago
An improved method for identifying functionally linked proteins using phylogenetic profiles
Background: Phylogenetic profiles record the occurrence of homologs of genes across fully sequenced organisms. Proteins with similar profiles are typically components of protein c...
Shawn Cokus, Sayaka Mizutani, Matteo Pellegrini
EXPERT
2006
156views more  EXPERT 2006»
15 years 6 months ago
Computational Models of Ethical Reasoning: Challenges, Initial Steps, and Future Directions
on abstract principles that you can't easily apply in a formal, deductive fashion. So, the favorite tools of logicians and mathematicians, such as firstorder logic, aren'...
Bruce M. McLaren
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