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150
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BMCBI
2007
15 years 6 months ago
2007
Background: Peptidases are proteolytic enzymes responsible for fundamental cellular activities in all organisms. Apparently about 2–5% of the genes encode for peptidases, irresp...
198
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BMCBI
2007
15 years 6 months ago
2007
Background: The Affymetrix™ technology is nowadays a well-established method for the analysis of gene expression profiles in cancer research studies. However, changes in gene ex...
156
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BMCBI
2007
15 years 6 months ago
2007
Background: Support Vector Machines (SVMs) provide a powerful method for classification (supervised learning). Use of SVMs for clustering (unsupervised learning) is now being cons...
184
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BMCBI
2007
15 years 6 months ago
2007
Background: Mean-based clustering algorithms such as bisecting k-means generally lack robustness. Although componentwise median is a more robust alternative, it can be a poor cent...
148
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BMCBI
2007
15 years 6 months ago
2007
Background: Hidden Markov Models (HMMs) provide an excellent means for structure identification and feature extraction on stochastic sequential data. An HMM-with-Duration (HMMwD) ...