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BMCBI
2006
128views more  BMCBI 2006»
15 years 6 months ago
Comparative assessment of performance and genome dependence among phylogenetic profiling methods
Background: The rapidly increasing speed with which genome sequence data can be generated will be accompanied by an exponential increase in the number of sequenced eukaryotes. Wit...
Evan S. Snitkin, Adam M. Gustafson, Joseph C. Mell...
BMCBI
2006
129views more  BMCBI 2006»
15 years 6 months ago
Improved alignment quality by combining evolutionary information, predicted secondary structure and self-organizing maps
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
BMCBI
2006
94views more  BMCBI 2006»
15 years 6 months ago
Noise-injected neural networks show promise for use on small-sample expression data
Background: Overfitting the data is a salient issue for classifier design in small-sample settings. This is why selecting a classifier from a constrained family of classifiers, on...
Jianping Hua, James Lowey, Zixiang Xiong, Edward R...
BMCBI
2006
127views more  BMCBI 2006»
15 years 6 months ago
PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens
Background: Here we describe PathogenMIPer, a software program for designing molecular inversion probe (MIP) oligonucleotides for use in pathogen identification and detection. The...
Sreedevi Thiyagarajan, Miloslav Karhanek, Michael ...
BMCBI
2006
156views more  BMCBI 2006»
15 years 6 months ago
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...
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