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BMCBI
2007
130views more  BMCBI 2007»
15 years 6 months ago
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base
Background: G Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological ...
Lucy Skrabanek, Marta Murcia, Michel Bouvier, Laks...
BMCBI
2007
121views more  BMCBI 2007»
15 years 6 months ago
A constrained polynomial regression procedure for estimating the local False Discovery Rate
Background: In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which...
Cyril Dalmasso, Avner Bar-Hen, Philippe Broët
BMCBI
2008
122views more  BMCBI 2008»
15 years 6 months ago
ESLpred2: improved method for predicting subcellular localization of eukaryotic proteins
Background: The expansion of raw protein sequence databases in the post genomic era and availability of fresh annotated sequences for major localizations particularly motivated us...
Aarti Garg, Gajendra P. S. Raghava
BMCBI
2007
157views more  BMCBI 2007»
15 years 6 months ago
Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
Feng Luo, Yunfeng Yang, Jianxin Zhong, Haichun Gao...
BMCBI
2007
143views more  BMCBI 2007»
15 years 6 months ago
An adaptive bin framework search method for a beta-sheet protein homopolymer model
Background: The problem of protein structure prediction consists of predicting the functional or native structure of a protein given its linear sequence of amino acids. This probl...
Alena Shmygelska, Holger H. Hoos
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