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196
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BMCBI
2010
15 years 6 months ago
2010
Background: The amount of available biological information is rapidly increasing and the focus of biological research has moved from single components to networks and even larger ...
179
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BMCBI
2010
15 years 6 months ago
2010
Background: Assembling genomic sequences from a set of overlapping reads is one of the most fundamental problems in computational biology. Algorithms addressing the assembly probl...
171
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BMCBI
2010
15 years 6 months ago
2010
Background: With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the ...
156
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BMCBI
2007
15 years 6 months ago
2007
Background: As a consequence of the evolutionary process, data collected from related species tend to be similar. This similarity by descent can obscure subtler signals in the dat...
191
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BMCBI
2008
15 years 6 months ago
2008
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...