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BMCBI
2010
189views more  BMCBI 2010»
15 years 6 months ago
High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH
Background: Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become...
Florian Teichert, Jonas Minning, Ugo Bastolla, Mar...
BMCBI
2008
89views more  BMCBI 2008»
15 years 6 months ago
R/parallel - speeding up bioinformatics analysis with R
Background: R is the preferred tool for statistical analysis of many bioinformaticians due in part to the increasing number of freely available analytical methods. Such methods ca...
Gonzalo Vera, Ritsert C. Jansen, Remo Suppi
BMCBI
2007
120views more  BMCBI 2007»
15 years 6 months ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins
BMCBI
2010
151views more  BMCBI 2010»
15 years 6 months ago
Misty Mountain clustering: application to fast unsupervised flow cytometry gating
Background: There are many important clustering questions in computational biology for which no satisfactory method exists. Automated clustering algorithms, when applied to large,...
István P. Sugár, Stuart C. Sealfon
BMCBI
2010
105views more  BMCBI 2010»
15 years 6 months ago
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement
Background: The Medium-chain Dehydrogenases/Reductases (MDR) form a protein superfamily whose size and complexity defeats traditional means of subclassification; it currently has ...
Joel Hedlund, Hans Jörnvall, Bengt Persson
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