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ALMOB
2006
109views more  ALMOB 2006»
15 years 6 months ago
A novel functional module detection algorithm for protein-protein interaction networks
Background: The sparse connectivity of protein-protein interaction data sets makes identification of functional modules challenging. The purpose of this study is to critically eva...
Woochang Hwang, Young-Rae Cho, Aidong Zhang, Mural...
TCC
2009
Springer
141views Cryptology» more  TCC 2009»
16 years 7 months ago
Weak Verifiable Random Functions
Verifiable random functions (VRFs), introduced by Micali, Rabin and Vadhan, are pseudorandom functions in which the owner of the seed produces a public-key that constitutes a commi...
Zvika Brakerski, Shafi Goldwasser, Guy N. Rothblum...
BMCBI
2010
109views more  BMCBI 2010»
15 years 6 months ago
Predicting gene function using hierarchical multi-label decision tree ensembles
Background: S. cerevisiae, A. thaliana and M. musculus are well-studied organisms in biology and the sequencing of their genomes was completed many years ago. It is still a challe...
Leander Schietgat, Celine Vens, Jan Struyf, Hendri...
BMCBI
2010
160views more  BMCBI 2010»
15 years 6 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
BMCBI
2008
102views more  BMCBI 2008»
15 years 6 months ago
Improving protein function prediction methods with integrated literature data
Background: Determining the function of uncharacterized proteins is a major challenge in the post-genomic era due to the problem's complexity and scale. Identifying a protein...
Aaron Gabow, Sonia M. Leach, William A. Baumgartne...