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BMCBI
2010
82views more  BMCBI 2010»
15 years 7 months ago
Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
Background: Metabolic pathway is a highly regulated network consisting of many metabolic reactions involving substrates, enzymes, and products, where substrates can be transformed...
Lei Chen, Kai-Yan Feng, Yu-Dong Cai, Kuo-Chen Chou...
BMCBI
2007
102views more  BMCBI 2007»
15 years 7 months ago
FlexOracle: predicting flexible hinges by identification of stable domains
Background: Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions i...
Samuel Flores, Mark Gerstein
212
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BCB
2010
140views Bioinformatics» more  BCB 2010»
15 years 1 months ago
Guiding belief propagation using domain knowledge for protein-structure determination
A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
Ameet Soni, Craig A. Bingman, Jude W. Shavlik
HPCA
2005
IEEE
16 years 7 months ago
Voltage and Frequency Control With Adaptive Reaction Time in Multiple-Clock-Domain Processors
Dynamic voltage and frequency scaling (DVFS) is a widely-used method for energy-efficient computing. In this paper, we present a new intra-task online DVFS scheme for multiple clo...
Qiang Wu, Philo Juang, Margaret Martonosi, Douglas...
FOCS
2005
IEEE
16 years 14 days ago
Learning mixtures of product distributions over discrete domains
We consider the problem of learning mixtures of product distributions over discrete domains in the distribution learning framework introduced by Kearns et al. [18]. We give a poly...
Jon Feldman, Ryan O'Donnell, Rocco A. Servedio