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160
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BMCBI
2008
15 years 7 months ago
2008
Background: Modelling proteins with multiple domains is one of the central challenges in Structural Biology. Although homology modelling has successfully been applied for predicti...
177
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BMCBI
2008
15 years 7 months ago
2008
Background: Tight clustering arose recently from a desire to obtain tighter and potentially more informative clusters in gene expression studies. Scattered genes with relatively l...
201
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BMCBI
2006
15 years 7 months ago
2006
Background: Particle Swarm Optimization (PSO) is an established method for parameter optimization. It represents a population-based adaptive optimization technique that is influen...
180
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BMCBI
2006
15 years 7 months ago
2006
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
206
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BMCBI
2006
15 years 7 months ago
2006
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...