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BMCBI
2008
92views more  BMCBI 2008»
15 years 6 months ago
A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles
Background: The discovery of biomarkers is an important step towards the development of criteria for early diagnosis of disease status. Recently electrospray ionization (ESI) and ...
Samiran Ghosh, David F. Grant, Dipak K. Dey, Denni...
BMCBI
2008
176views more  BMCBI 2008»
15 years 6 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
CSCL
2008
106views more  CSCL 2008»
15 years 6 months ago
Operationalizing macro-scripts in CSCL technological settings
: This paper presents a conceptual analysis of the technological dimensions related to the operationalization of CSCL macro-scripts. CSCL scripts are activity models that aim at en...
Pierre Tchounikine
ALMOB
2006
155views more  ALMOB 2006»
15 years 6 months ago
Refining motifs by improving information content scores using neighborhood profile search
The main goal of the motif finding problem is to detect novel, over-represented unknown signals in a set of sequences (e.g. transcription factor binding sites in a genome). The mo...
Chandan K. Reddy, Yao-Chung Weng, Hsiao-Dong Chian...
BMCBI
2006
102views more  BMCBI 2006»
15 years 6 months ago
SNA - a toolbox for the stoichiometric analysis of metabolic networks
Background: Despite recent algorithmic and conceptual progress, the stoichiometric network analysis of large metabolic models remains a computationally challenging problem. Result...
Robert Urbanczik