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174
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BMCBI
2010
2010
On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence
15 years 6 months ago
Background: In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput gen...
181
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BMCBI
2010
15 years 6 months ago
2010
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
188
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BMCBI
2010
15 years 6 months ago
2010
Background: In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other high-throughput t...
145
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BMCBI
2010
15 years 6 months ago
2010
Background: Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. H...
166
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BMCBI
2010
15 years 6 months ago
2010
Background: Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restriction...