Under a stochastic model of molecular sequence evolution the probability of each possible pattern of characters is well defined. The Kimura's three-substitution-types (K3ST) m...
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
We propose a novel statistical approach to detect defects in digitized archive film by using temporal information across a number of frames modeled with an HMM. The HMM is traine...
Background: The residue-wise contact order (RWCO) describes the sequence separations between the residues of interest and its contacting residues in a protein sequence. It is a ne...
Background: Metagenomics is the study of environmental samples using sequencing. Rapid advances in sequencing technology are fueling a vast increase in the number and scope of met...