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» Efficient protein alignment algorithm for protein search
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BMCBI
2006
103views more  BMCBI 2006»
15 years 6 months ago
Domain-based small molecule binding site annotation
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
Kevin A. Snyder, Howard J. Feldman, Michel Dumonti...
BMCBI
2002
108views more  BMCBI 2002»
15 years 5 months ago
A memory-efficient dynamic programming algorithm for optimal alignment of a sequence to an RNA secondary structure
Background: Covariance models (CMs) are probabilistic models of RNA secondary structure, analogous to profile hidden Markov models of linear sequence. The dynamic programming algo...
Sean R. Eddy
BMCBI
2010
139views more  BMCBI 2010»
15 years 6 months ago
MOTIPS: Automated Motif Analysis for Predicting Targets of Modular Protein Domains
Background: Many protein interactions, especially those involved in signaling, involve short linear motifs consisting of 5-10 amino acid residues that interact with modular protei...
Hugo Y. K. Lam, Philip M. Kim, Janine Mok, Raffi T...
BMCBI
2006
144views more  BMCBI 2006»
15 years 6 months ago
ProFAT: a web-based tool for the functional annotation of protein sequences
Background: The functional annotation of proteins relies on published information concerning their close and remote homologues in sequence databases. Evidence for remote sequence ...
Charles Richard Bradshaw, Vineeth Surendranath, Bi...
CSB
2004
IEEE
149views Bioinformatics» more  CSB 2004»
15 years 9 months ago
Weighting Features to Recognize 3D Patterns of Electron Density in X-Ray Protein Crystallography
Feature selection and weighting are central problems in pattern recognition and instance-based learning. In this work, we discuss the challenges of constructing and weighting feat...
Kreshna Gopal, Tod D. Romo, James C. Sacchettini, ...