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» Efficient protein alignment algorithm for protein search
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BMCBI
2010
150views more  BMCBI 2010»
15 years 6 months ago
Evolutionary rates at codon sites may be used to align sequences and infer protein domain function
Background: Sequence alignments form part of many investigations in molecular biology, including the determination of phylogenetic relationships, the prediction of protein structu...
Pierre M. Durand, Scott Hazelhurst, Theresa L. Coe...
RECOMB
2003
Springer
16 years 6 months ago
Accurate detection of very sparse sequence motifs
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Andreas Heger, Michael Lappe, Liisa Holm
FPL
2004
Springer
109views Hardware» more  FPL 2004»
15 years 11 months ago
Hardware Accelerated Novel Protein Identification
The proteins in living organisms perform almost every significant function that governs life. A protein's functionality depends upon its physical structure, which depends on i...
Anish Alex, Jonathan Rose, Ruth Isserlin-Weinberge...
GECCO
2004
Springer
137views Optimization» more  GECCO 2004»
15 years 11 months ago
Evolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
Luke Sheneman, James A. Foster
JCB
2006
107views more  JCB 2006»
15 years 6 months ago
Protein Image Alignment via Piecewise Affine Transformations
Abstract We present a new approach for aligning families of 2D gels. Instead of choosing one of the gels as reference and performing pairwise alignment, we construct an ideal gel t...
Florian A. Potra, Xing Liu, Françoise Seill...