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BMCBI
2010
96views more  BMCBI 2010»
15 years 6 months ago
QTLminer: identifying genes regulating quantitative traits
Background: Quantitative trait locus (QTL) mapping identifies genomic regions that likely contain genes regulating a quantitative trait. However, QTL regions may encompass tens to...
Rudi Alberts, Klaus Schughart
BMCBI
2008
115views more  BMCBI 2008»
15 years 6 months ago
Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient
Background: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson corre...
Jianchao Yao, Chunqi Chang, Mari L. Salmi, Yeung S...
BMCBI
2010
172views more  BMCBI 2010»
15 years 6 months ago
Inferring gene regression networks with model trees
Background: Novel strategies are required in order to handle the huge amount of data produced by microarray technologies. To infer gene regulatory networks, the first step is to f...
Isabel A. Nepomuceno-Chamorro, Jesús S. Agu...
BMCBI
2007
133views more  BMCBI 2007»
15 years 6 months ago
MATLIGN: a motif clustering, comparison and matching tool
Background: Sequence motifs representing transcription factor binding sites (TFBS) are commonly encoded as position frequency matrices (PFM) or degenerate consensus sequences (CS)...
Matti Kankainen, Ari Löytynoja
BMCBI
2008
89views more  BMCBI 2008»
15 years 6 months ago
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
Background: Simulating the major molecular events inside an Escherichia coli cell can lead to a very large number of reactions that compose its overall behaviour. Not only should ...
Marco A. J. Iafolla, Guang Qiang Dong, David R. Mc...
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