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180
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BMCBI
2007
15 years 6 months ago
2007
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
139
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BMCBI
2007
15 years 6 months ago
2007
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
164
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BMCBI
2007
15 years 6 months ago
2007
Background: Used alone, the MAS5.0 algorithm for generating expression summaries has been criticized for high False Positive rates resulting from exaggerated variance at low inten...
218
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BMCBI
2007
15 years 6 months ago
2007
High-throughput methods can directly detect the set of interacting proteins in yeast but the results are often incomplete and exhibit high false positive and false negative rates....
193
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JCB
2006
15 years 6 months ago
2006
Biological systems are traditionally studied by focusing on a specific subsystem, building an intuitive model for it, and refining the model using results from carefully designed ...