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BMCBI
2010
135views more  BMCBI 2010»
15 years 6 months ago
HDAPD: a web tool for searching the disease-associated protein structures
Background: The protein structures of the disease-associated proteins are important for proceeding with the structure-based drug design to against a particular disease. Up until n...
Yi-Ruen Lin, Hsin-Yuan Wei, Tsung-Lin Tsai, Thy-Ho...
BMCBI
2010
208views more  BMCBI 2010»
15 years 6 months ago
Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene
Background: Image analysis is an essential component in many biological experiments that study gene expression, cell cycle progression, and protein localization. A protocol for tr...
Zafer Aydin, John I. Murray, Robert H. Waterston, ...
BMCBI
2010
113views more  BMCBI 2010»
15 years 6 months ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
BMCBI
2010
109views more  BMCBI 2010»
15 years 6 months ago
Free energy estimation of short DNA duplex hybridizations
Background: Estimation of DNA duplex hybridization free energy is widely used for predicting cross-hybridizations in DNA computing and microarray experiments. A number of software...
Dan C. Tulpan, Mirela Andronescu, Serge Leger
BMCBI
2010
133views more  BMCBI 2010»
15 years 6 months ago
Improving de novo sequence assembly using machine learning and comparative genomics for overlap correction
Background: With the rapid expansion of DNA sequencing databases, it is now feasible to identify relevant information from prior sequencing projects and completed genomes and appl...
Lance E. Palmer, Mathäus Dejori, Randall A. B...
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