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BMCBI
2007
109views more  BMCBI 2007»
15 years 6 months ago
A cis-regulatory logic simulator
Background: A major goal of computational studies of gene regulation is to accurately predict the expression of genes based on the cis-regulatory content of their promoters. The d...
Robert D. Zeigler, Jason Gertz, Barak A. Cohen
BMCBI
2007
102views more  BMCBI 2007»
15 years 6 months ago
Understanding and using the meaning of statements in a bio-ontology: recasting the Gene Ontology in OWL
The bio-ontology community falls into two camps: first we have biology domain experts, who actually hold the knowledge we wish to capture in ontologies; second, we have ontology s...
Mikel Egaña Aranguren, Sean Bechhofer, Phil...
BMCBI
2008
143views more  BMCBI 2008»
15 years 6 months ago
Automatic detection of exonic splicing enhancers (ESEs) using SVMs
Background: Exonic splicing enhancers (ESEs) activate nearby splice sites and promote the inclusion (vs. exclusion) of exons in which they reside, while being a binding site for S...
Britta Mersch, Alexander Gepperth, Sándor S...
BMCBI
2008
166views more  BMCBI 2008»
15 years 6 months ago
Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual informa
Background: Probability based statistical learning methods such as mutual information and Bayesian networks have emerged as a major category of tools for reverse engineering mecha...
Weijun Luo, Kurt D. Hankenson, Peter J. Woolf
BMCBI
2008
83views more  BMCBI 2008»
15 years 6 months ago
Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
Background: Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of...
Atsushi Niida, Andrew D. Smith, Seiya Imoto, Shuic...
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