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» Conservativity in Structured Ontologies
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BMCBI
2007
112views more  BMCBI 2007»
15 years 6 months ago
PFAAT version 2.0: A tool for editing, annotating, and analyzing multiple sequence alignments
Background: By virtue of their shared ancestry, homologous sequences are similar in their structure and function. Consequently, multiple sequence alignments are routinely used to ...
Daniel R. Caffrey, Paul H. Dana, Vidhya Mathur, Ma...
DAGSTUHL
2006
15 years 7 months ago
Are we Ready to Embrace the Semantic Web?
action from low level features to high level semantics. Owing to the proliferation of multimedia content in the internet, there is widespread interest in the semantic web community...
Shankar Vembu, Stephan Baumann
ALMOB
2006
155views more  ALMOB 2006»
15 years 6 months ago
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
Jonathan E. Allen, Steven L. Salzberg
BMCBI
2004
96views more  BMCBI 2004»
15 years 6 months ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
BMCBI
2004
177views more  BMCBI 2004»
15 years 6 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu