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» Computing with Evolving Proteins
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BMCBI
2008
102views more  BMCBI 2008»
15 years 6 months ago
Fast splice site detection using information content and feature reduction
Background: Accurate identification of splice sites in DNA sequences plays a key role in the prediction of gene structure in eukaryotes. Already many computational methods have be...
A. K. M. A. Baten, Saman K. Halgamuge, Bill C. H. ...
BMCBI
2006
120views more  BMCBI 2006»
15 years 6 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
BMCBI
2006
116views more  BMCBI 2006»
15 years 6 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
BMCBI
2005
110views more  BMCBI 2005»
15 years 6 months ago
Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information
Background: The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their...
James W. Cooper, Aaron Kershenbaum
BMCBI
2004
126views more  BMCBI 2004»
15 years 6 months ago
Visualization and analysis of microarray and gene ontology data with treemaps
Background: The increasing complexity of genomic data presents several challenges for biologists. Limited computer monitor views of data complexity and the dynamic nature of data ...
Eric H. Baehrecke, Niem Dang, Ketan Babaria, Ben S...