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STOC
2003
ACM
124views Algorithms» more  STOC 2003»
16 years 6 months ago
Extractors: optimal up to constant factors
This paper provides the first explicit construction of extractors which are simultaneously optimal up to constant factors in both seed length and output length. More precisely, fo...
Chi-Jen Lu, Omer Reingold, Salil P. Vadhan, Avi Wi...
CSB
2005
IEEE
125views Bioinformatics» more  CSB 2005»
15 years 12 months ago
Discriminative Discovery of Transcription Factor Binding Sites from Location Data
Motivation: The availability of genome-wide location analyses based on chromatin immunoprecipitation (ChIP) data gives a new insight for in silico analysis of transcriptional regu...
Yuji Kawada, Yasubumi Sakakibara
BMCBI
2007
174views more  BMCBI 2007»
15 years 6 months ago
Inferring activity changes of transcription factors by binding association with sorted expression profiles
Background: The identification of transcription factors (TFs) associated with a biological process is fundamental to understanding its regulatory mechanisms. From microarray data,...
Chao Cheng, Xiting Yan, Fengzhu Sun, Lei M. Li
BMCBI
2006
170views more  BMCBI 2006»
15 years 6 months ago
Biclustering of gene expression data by non-smooth non-negative matrix factorization
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
Pedro Carmona-Saez, Roberto D. Pascual-Marqui, Fra...
BMCBI
2007
149views more  BMCBI 2007»
15 years 6 months ago
Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors
Background: Evolutionary conservation has been used successfully to help identify cis-acting DNA regions that are important in regulating tissue-specific gene expression. Motivate...
Xueping Yu, Jimmy J. Lin, Donald J. Zack, Jiang Qi...