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» Computational Challenges of Systems Biology
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ISMB
1998
15 years 8 months ago
Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
Wedescribe a prototype system (Poly-X) for assisting an expert user in modelingprotein repeats. Poly-X reduces the large numberof degrees of freedomrequired to specify a protein m...
Richard H. Lathrop, Malcolm S. Casale, Douglas J. ...
ISMB
1993
15 years 8 months ago
Knowledge-Based Generation of Machine-Learning Experiments: Learning with DNA Crystallography Data
Thoughit has been possible in the past to learn to predict DNAhydration patterns from crystallographic data, there is ambiguity in the choice of training data (both in terms of th...
Dawn M. Cohen, Casimir A. Kulikowski, Helen Berman
190
Voted
CORR
2010
Springer
174views Education» more  CORR 2010»
15 years 6 months ago
Hybrid Numerical Solution of the Chemical Master Equation
We present a numerical approximation technique for the analysis of continuous-time Markov chains that describe networks of biochemical reactions and play an important role in the ...
Thomas A. Henzinger, Maria Mateescu, Linar Mikeev,...
RECOMB
2012
Springer
13 years 9 months ago
Reconstructing Boolean Models of Signaling
Abstract. Since the first emergence of protein-protein interaction networks, more than a decade ago, they have been viewed as static scaffolds of the signaling-regulatory events ...
Roded Sharan, Richard M. Karp
149
Voted
IDMS
2001
Springer
138views Multimedia» more  IDMS 2001»
15 years 11 months ago
New Resource Control Issues in Shared Clusters
—We claim that the renting of machine resources on clusters of servers introduces new systems challenges which are different from those hitherto encountered, either in multimedia...
Timothy Roscoe, Prashant J. Shenoy