The problem of sorting a signed permutation by reversals is inspired by genome rearrangements in computational molecular biology. Given two genomes represented as two signed permut...
We introduce in this paper a generalization of the widely used hidden Markov models (HMM's), which we name "structural hidden Markov models" (SHMM). Our approach is ...
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The reg...
Constructing quantitative dynamic models of signaling pathways is an important task for computational systems biology. Pathway model construction is often an inherently incremental...
Artificial neural networks, electronic circuits, and gene networks are some examples of systems that can be modeled as networks, that is, as collections of interconnected nodes. I...
Mattiussi, Claudio, Dürr, Peter, Marbach, Daniel ...