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ISMB
1998
15 years 8 months ago
Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
Wedescribe a prototype system (Poly-X) for assisting an expert user in modelingprotein repeats. Poly-X reduces the large numberof degrees of freedomrequired to specify a protein m...
Richard H. Lathrop, Malcolm S. Casale, Douglas J. ...
ISMB
1998
15 years 8 months ago
Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model
A hidden Markov model of signal peptides has been developed. It contains submodels for the N-terminal part, the hydrophobic region, and the region around the cleavage site. For kn...
Henrik Nielsen, Anders Krogh
ISMB
1998
15 years 8 months ago
Bayesian Protein Family Classifier
A Bayesian procedure for the simultaneous alignment and classification of sequences into subclasses is described. This Gibbs sampling algorithm iterates between an alignment step ...
Kunbin Qu, Lee Ann McCue, Charles E. Lawrence
ISMB
1998
15 years 8 months ago
Automated Clustering and Assembly of Large EST Collections
The avMlability of large EST(Expressed Sequence Tag)databases has led to a revolution in the waynew genes are cloned. Difficulties arise, however,due to high error rates and redun...
David P. Yee, Darrell Conklin
ISMB
2000
15 years 8 months ago
Prediction of the Number of Residue Contacts in Proteins
Knowing the number of residue contacts in a protein is crucial for deriving constraints useful in modeling protein folding, protein structure, and/or scoring remote homology searc...
Piero Fariselli, Rita Casadio